Faculty Research 1970 - 1979

Title

T lymphocyte response to H-2 mutants: cytotoxic effectors are Ly-1+2+.

Document Type

Article

Publication Date

1979

Keywords

Cytotoxicity-Immunologic, Genes-Immune-Response, H-2-Antigens: ge, Isoantigens: ge, Leukocyte-Culture-Test-Mixed, Lymphocyte-Transformation, Mice, Mutation, Phenotype, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes: im

JAX Source

Proc-Natl-Acad-Sci-USA. 1979 Jul; 76(7):3455-9.

Abstract

The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kba and H-2Dda alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis demonstrated that the mutant-specific T cells were Ly-1+2+. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1+2+, demonstrated that Ly-1+2+ T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of responsive T cells.

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