Faculty Research 1970 - 1979

Title

Properties and biosynthesis of cyclopropane fatty acids in Escherichia coli.

Document Type

Article

Publication Date

1979

Keywords

Escherichia-Coli: me, Fatty-Acids: an, bi, Genes, Methionine: me, Mutation, Phospholipids: an, S-Adenosylmethionine: me, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J-Bacteriol. 1979 Apr; 138(1):118-21.

Abstract

The lipid phase transition of Escherichia coli phospholipids containing cyclopropane fatty acids was compared with the otherwise homologous phospholipids lacking cyclopropane fatty acids. The phase transitions (determined by scanning calorimetry) of the two preparations were essentially identical. Infection of E. coli with phage T3 inhibited cyclopropane fatty acid formation over 98%, whereas infection with mutants which lack the phage coded S-adenosylmethionine cleavage enzyme had no effect on cyclopropane fatty acid synthesis. These data indicate that S-adenosylmethionine is the methylene in cyclopropane fatty acid synthesis.

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