Faculty Research 1970 - 1979

Title

[A study of H-2 mutations in mice. V. Detection of mutations M505, Hzl and M506 in the host vs transplant reaction]

Document Type

Article

Publication Date

1975

Keywords

English-Abstract, Graft-Vs-Host-Reaction: fg, im, Histocompatibility-Antigens, Mice, Mice-Inbred-Strains, Mutation, Spleen: im, tr, Transplantation-Homologous

JAX Source

Genetika. 1975; 11(10):30-2.

Abstract

H-2 mutant/normal pairs of congenic mouse strains C57BL/6equilibriumB6.M505 (H-2Kbd), C57BL/6equilibriumB6.C(Hz1) (H-2Kba) and A.CAequilibriumA.CA(M506) (H-2fa) were studied in the graft versus host assay. All the three mutations were expressed in these tests as gain and loss of H-2 antigen. The data obtained confirm an earlier suggestion that the H-2K antigenic molecule bears antigenic determinants which could be detected by a variety of immunological techniques.

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