Growth of human normal and neoplastic mammary tissues in the cleared mammary fat pad of the nude mouse.

Authors

H C. Outzen
R P. Custer

Document Type

Article

Publication Date

1975

Keywords

Breast: tr, Breast-Neoplasms: pa, Female, Germ-Free-Life, Human, Mice, Mice-Nude, Neoplasm-Transplantation, SUPPORT-U-S-GOVT-P-H-S, Transplantation-Heterologous

First Page

1461

Last Page

1466

JAX Source

J-Natl-Cancer-Inst. 1975 Dec; 55(6):1461-6.

Abstract

Dysplastic and malignant human breast tissues were grown successfully in the cleared mammary fat pads (CFP) of nude mice. The mammary fat pads were cleared while the mice were in a germfree isolator. Prepared mice were removed fron the germfree enviornment to facilitate transplantation of the human mammary tissue into their CFP and subsequently were maintained in sterile laminar flow racks.

Recommended Citation

Outzen HC, Custer RP. Growth of human normal and neoplastic mammary tissues in the cleared mammary fat pad of the nude mouse. J-Natl-Cancer-Inst. 1975 Dec; 55(6):1461-6.