Faculty Research 1970 - 1979

Title

Mitochondrial malate dehydrogenase (Mor-1) in the mouse: linkage to chromosome 5 markers.

Document Type

Article

Publication Date

1975

Keywords

Animal, Chromosome-Mapping, Crosses-Genetic, Female, Genotype, Glucuronidase: an, Kidney: en, Linkage-(Genetics), Malate-Dehydrogenase: an, Male, Mice, Mice-Inbred-CBA, Mice-Inbred-C57BL, Mitochondria: en, Recombination-Genetic, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Biochem-Genet. 1975 Oct; 13(9-10):519-25.

Abstract

Malate dehydrogenase is present in most mammalian tissues in both supernatant and mitochondrial forms. Although genetic variation for the supernatant form has not been observed in the mouse, electrophoretic variants caused by alleles at the mitochondrial locus (Mor-1) have been previously described. We have located this locus 11.0 +/- 2.9 cM from the beta-glucuronidase structural gene, Gus, on chromosome 5. The gene order is Hm-Pgm-1-rd-bf-Gus-Mor-1. Thus Mor-1 is presently the most distal marker on chromosome 5. Three different nuclear loci for mitochondrial enzymes (Mod-2, Got-2, and Mor-1) have now been mapped in the mouse, all on different chromosomes.

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