Faculty Research 1970 - 1979

Title

Genes associated with leukocyte production in mice.

Authors

C K. Chai

Document Type

Article

Publication Date

1975

Keywords

Crosses-Genetic, Genes, Hematopoiesis, Hybridization, Leukocyte-Count, Leukocytes, Linkage-(Genetics), Mice, SUPPORT-U-S-GOVT-P-H-S

JAX Location

41,016

JAX Source

J-Hered. 1975 Sep-Oct; 66(5):301-8.

Abstract

We have investigated the genes influencing leukocyte production in mice by selective breeding for differences in leukocyte count and developed two major lines differing about 8-fold. In these lines we have made counter selective breeding, crossbreeding between them, and developed methods of using marker genes to search for individual genes distributed on different chromosomes. We have revealed an overall dominance of genes for low leukocyte count over those for high counts, and effects of genes at the agouti locus, certain mutant genes, and a gene or genes in the XVI linkage group. We have commented on the application and approach of quantitative genetic experimentation from both a theoretical and practical point of view and, on the basis of present results, discussed the nature of polygenes in relation to genes causing polymorphisms.

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