Faculty Research 1970 - 1979
Lactate dehydrogenase X: effects of antibody on mouse gametes but not on early development.
Document Type
Article
Publication Date
1975
Keywords
Antibodies, Embryo: im, Female, Fertilization, Immune-Sera, Lactate-Dehydrogenase: im, Male, Mice, Ovum: im, Pregnancy, Rabbits: im, Spermatozoa: en, im, SUPPORT-U-S-GOVT-P-H-S
First Page
261
Last Page
263
JAX Location
41,032
JAX Source
Science. 1975 Apr 18; 188(4185):261-3.
Abstract
A rabbit antiserum specific for LDH-X, the spermatozoal form of mouse lactate dehydrogenase, was prepared. This antiserum had no effect on fertility of female mice when injected before or after insemination. Similarly, there was no toxicity to the embryo when high concentrations of the antiserum were added to cultures of 2-cell and 8- to 16-cell embryos. There was, however, a moderate inhibitory effect on fertilization in vitro, which may be attributable to a direct action of antiserum to LDH-X on sperm.
Recommended Citation
Erickson RP,
Hoppe PC,
Tennenbaum D,
Spielmann H,
Epstein CJ.
Lactate dehydrogenase X: effects of antibody on mouse gametes but not on early development. Science. 1975 Apr 18; 188(4185):261-3.