Faculty Research 1970 - 1979

Title

Lactate dehydrogenase X: effects of antibody on mouse gametes but not on early development.

Document Type

Article

Publication Date

1975

Keywords

Antibodies, Embryo: im, Female, Fertilization, Immune-Sera, Lactate-Dehydrogenase: im, Male, Mice, Ovum: im, Pregnancy, Rabbits: im, Spermatozoa: en, im, SUPPORT-U-S-GOVT-P-H-S

JAX Location

41,032

JAX Source

Science. 1975 Apr 18; 188(4185):261-3.

Abstract

A rabbit antiserum specific for LDH-X, the spermatozoal form of mouse lactate dehydrogenase, was prepared. This antiserum had no effect on fertility of female mice when injected before or after insemination. Similarly, there was no toxicity to the embryo when high concentrations of the antiserum were added to cultures of 2-cell and 8- to 16-cell embryos. There was, however, a moderate inhibitory effect on fertilization in vitro, which may be attributable to a direct action of antiserum to LDH-X on sperm.

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