Faculty Research 1970 - 1979

Title

Macrophage-mediated cytotoxicity: its possible role in rheumatoid arthritis.

Authors

R Evans

Document Type

Article

Publication Date

1975

Keywords

Antigen-Antibody-Complex, Antigenic-Determinants, Arthritis-Rheumatoid: im, pa, Cytotoxicity-Tests-Immunologic, Human, Hydrolases: bi, Immunity-Cellular, Macrophages: en, im, Mice, Neoplasms: im, Rats, Synovial-Membrane: pa, Transplantation-Immunology

JAX Source

Ann-NY-Acad-Sci. 1975 Jun 13; 256:275-87.

Abstract

The association of macrophages with destructive processes in transplantation and tumoral, bacterial, and protozoan immunity illustrates their versatility in different situations. Their participation in inflammatory responses, including graft rejection and rheumatoid arthritis, would guarantee focal areas of high concentrations of hydrolytic enzymes and other macrophage products. That erosion of synovial tissue occurs in the presence of enzymes known to be associated with macrophages suggests that the large numbers of infiltrating macrophages and destruction of synovial tissue may be related.

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