Faculty Research 1970 - 1979

Title

Ultrastructure of ovarian teratomas in LT mice.

Document Type

Article

Publication Date

1975

Keywords

Cell-Differentiation, Cell-Nucleus: ul, Endoplasmic-Reticulum: ul, Female, Granulosa-Cells: ul, Inclusion-Bodies-Viral: ul, Mice, Mice-Inbred-Strains, Neoplasms-Experimental, Nerve-Tissue: ul, Organoids: ul, Ovarian-Neoplasms: pa, Ovum: ul, SUPPORT-U-S-GOVT-P-H-S, Teratoma: pa

JAX Source

Z-Krebsforsch. 1975 Aug 8; 83(4):261-7.

Abstract

Stem cells of these tumors formed nests consisting of undifferentiated embryonic cells in the center with more differentiated cells towards the periphery. A type viral particles were seen in the cisternae of rough endoplasmic reticulum. Ultrastructurally the stem cells of ovarian teratomas did not differ from stem cells of testicular or embryo-derived teratomas. They were however distinct from the cleavage stage embryonic cells and/or the unfertilized ovum, they stemmed from. They correspond both cytologically and developmentally to ectodermal embryonic cells from the egg-cylinder, the most advanced developmental stage of parthenotes observed previously in the ovary of LT mice.

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