Faculty Research 1970 - 1979
Defective erythropoietic responses of aged mice not improved by young marrow.
Document Type
Article
Publication Date
1975
Keywords
Anemia-Aplastic: fg, th, Animal, Bloodletting, Bone-Marrow: cy, tr, Erythropoiesis, Female, Hematopoietic-Stem-Cells: ph, Mice, Mice-Inbred-C57BL, SUPPORT-U-S-GOVT-P-H-S, Transplantation-Homologous
First Page
286
Last Page
288
JAX Source
J-Gerontol. 1975 May; 30(3):286-8.
Abstract
Defective responses to severe bleeding in 25-mo.-old C57BL/6J mice were not improved by injections of 8-mo.-old marrow cells. Such injections greatly improved responses of genetically anemic W/W-v mice that have defective erythropoietic stem cells. Apparently the defective responses of old mice were not intrinsic to their erythropoietic stem cells.
Recommended Citation
Harrison DE.
Defective erythropoietic responses of aged mice not improved by young marrow. J-Gerontol. 1975 May; 30(3):286-8.