Faculty Research 1970 - 1979

Title

Presence of a high-molecular-weight RNA and RNA-directed DNA polymerase in rabbit hereditary lymphosarcoma.

Document Type

Article

Publication Date

1976

Keywords

C-Type-Viruses: en, Cells-Cultured, Female, Lymphoma-Non-Hodgkin's: fg, me, Male, Molecular-Weight, Polynucleotides: me, Rabbits, Reverse-Transcriptase: ip, RNA-Neoplasm: ip, RNA-Viral: ip, Sarcoma-Experimental: fg, me, mi, SUPPORT-U-S-GOVT-P-H-S

JAX Location

41,815

JAX Source

Cancer-Res. 1976 Dec; 36(12):4693-8.

Abstract

Rabbit lymphosarcoma tissues contain 70 S RNA and RNA-directed DNA polymerase encapsulated in particulate components that band in the density region of type C RNA viruses. RNA-directed DNA polymerase associated with the particles could be distinguished from cellular DNA polymerases by salt elution from phosphocellulose. The enzyme preferred the template primers poly(rA)-(dT)12-18 and poly(rC)-(dG)12-18 over other synthetic template primers and also utilized viral 70 S RNA as template; these properties are not observed with the known cellular DNA polymerases.

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