The etiology of transmissible murine colonic hyperplasia.

Authors

S W. Barthold
G L. Coleman
P N. Bhatt
G W. Osbaldiston
A M. Jonas

Document Type

Article

Publication Date

1976

Keywords

Citrobacter, Colon: pa, Colonic-Diseases: et, pa, ve, Enterobacteriaceae-Infections: et, pa, ve, Hyperplasia, Mice, Rodent-Diseases: et, pa, SUPPORT-U-S-GOVT-P-H-S

First Page

889

Last Page

894

JAX Source

Lab-Anim-Sci. 1976 Dec; 26:889-94.

Abstract

The etiology of a transmissable colonic mucosal hyperplasia of mice was investigated. Hyperplasia was produced in mice inoculated with unfiltered colonic suspension from affected mice, but infectivity was lost after passage through a 0.45 mum filter. The etiologic agent was subsequently identified as a variant of Citrobacter freundii. The organism induced colonic mucosal hyperplasia when inoculated into germfree mice, and it was recovered in pure culture from the affected animals.

Recommended Citation

Barthold SW, Coleman GL, Bhatt PN, Osbaldiston GW, Jonas AM. The etiology of transmissible murine colonic hyperplasia. Lab-Anim-Sci. 1976 Dec; 26:889-94.