Faculty Research 1970 - 1979

Title

The etiology of transmissible murine colonic hyperplasia.

Document Type

Article

Publication Date

1976

Keywords

Citrobacter, Colon: pa, Colonic-Diseases: et, pa, ve, Enterobacteriaceae-Infections: et, pa, ve, Hyperplasia, Mice, Rodent-Diseases: et, pa, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Lab-Anim-Sci. 1976 Dec; 26:889-94.

Abstract

The etiology of a transmissable colonic mucosal hyperplasia of mice was investigated. Hyperplasia was produced in mice inoculated with unfiltered colonic suspension from affected mice, but infectivity was lost after passage through a 0.45 mum filter. The etiologic agent was subsequently identified as a variant of Citrobacter freundii. The organism induced colonic mucosal hyperplasia when inoculated into germfree mice, and it was recovered in pure culture from the affected animals.

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