Faculty Research 1970 - 1979

Title

Evidence for a particle-associated RNA-directed DNA polymerase in rabbit placental and uterine tissues.

Document Type

Article

Publication Date

1976

Keywords

C-Type-Viruses: en, DNA-Polymerases: me, Female, Gestational-Age, Oligodeoxyribonucleotides: me, Placenta: en, mi, Poly-A: me, Poly-T: me, Polynucleotides: me, Pregnancy, Rabbits, Reverse-Transcriptase: ip, RNA-Viral: me, SUPPORT-U-S-GOVT-P-H-S, Uterus: en, mi

JAX Location

41,814

JAX Source

Cancer-Res. 1976 Dec; 36(12):4687-92.

Abstract

A RNA-directed DNA polymerase associated with particles that band at a density characteristic of type C RNA viruses was found in normal rabbit placental and uterine tissues taken during the early stages of gestation. That the rabbit RNA-directed DNA polymerase is distinct from the known cellular DNA polymerases and similar to the RNA-directed DNA polymerase of mammalian type C RNA viruses is shown by column chromatographic characteristics, template primer preferences, molecular weight determination, and an absolute requirement for the divalent cations.

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