Faculty Research 1970 - 1979

Title

Effect of allelic substitutions at the hairless locus on endogenous ecotropic murine leukemia virus titers and leukemogenesis.

Document Type

Article

Publication Date

1976

Keywords

Animal, Genes, Leukemia-Experimental: et, fg, Male, Mice, Mice-Nude: mi, Mouse-Leukemia-Viruses: ip, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J-Natl-Cancer-Inst. 1976 May; 56(5):1073-4.

Abstract

Leukemia-prone hairless (HRS/J; hr/hr) mice had significantly higher leukemia virus titers than did the leukemia-resistant nonmutants (hr/ + and +/+). This difference was ascribed to the allelic substitution at a single gene locus; at 6 months of age it averaged 13-fold, immediately preceding the large divergence in leukemia incidence between the mutant and nonmutant mice.

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