Faculty Research 1970 - 1979

Title

Strain distribution and linkage relationship of a mouse embryonic hemoglobin variant.

Document Type

Article

Publication Date

1976

Keywords

Animal, Crosses-Genetic, Embryo, Female, Fetal-Hemoglobin, Linkage-(Genetics), Macromolecular-Systems, Male, Mice, Mice-Inbred-C57BL, Mice-Inbred-Strains, Mutation, Phenotype, Pregnancy, Recombination-Genetic, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S, Variation-(Genetics)

JAX Source

Biochem-Genet. 1976 Apr; 14(3-4):373-81.

Abstract

Search for structural variants of three globin chains (x, y, z), synthesized only during mouse embryonic hematopoiesis, was carried out by electrophoretic analysis of blood from 12-day embryos, all with C57BL/6 mothers, and fathers from 115 inbred stocks selected for their diverse genetic origins. Structure of the beta-chains of adult hemoglobins differed among the tested strains, with 57 carrying the Hbbs allele, 56 the Hbbd allele, and two the Hbbp allele. The search revealed no x- or z-chain variants but confirmed and extended knowledge of a previously described y-chain variant. Blood of all embryos sired by males from the 57 Hbbs strains contained only y'-chains, while blood of au embryos sired by Hbbd or Hbbp males contained y2-chains as well as the y1-chains inherited from their C57BL/6 mother. The locus controlling structure of the y-chain of mouse embryonic hemoglobins is thus extremely closely linked to the locus controlling structure of adult hemoglobin beta-chain, with maximum possible recombination frequency less than 0.019.

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