Faculty Research 1970 - 1979

Title

Antibody-induced killing in vivo of L1210/MTX-R cells quantitated in passively immunized mice with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity.

Document Type

Article

Publication Date

1976

Keywords

Antibodies-Neoplasm, Cell-Survival, Complement: me, Cytotoxicity-Tests-Immunologic, Female, Idoxuridine, IgG, IgM, Immunity-Active: re, Immunization-Passive, Immunotherapy, Kinetics, Leukemia-L1210: im, th, Mercaptoethanol, Mice, Radiation-Effects, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J-Immunol. 1976 Sep; 117(3):822-9.

Abstract

The killing of the LR subline of the DBA/2J leukemia L1210/MTX by passive antibody was followed in vivo with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity. The in vivo killing of LR cells was proportional to the in vitro 2-mercaptoethanol resistant titer, independent of the complement system, and radioresistant. Although a large percentage of the leukemic cells was killed in passively immunized mice, the protective effect of the passive antiserum was dependent on the active immune response of the host.

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