Purkinje cell degeneration, a new neurological mutation in the mouse.

Authors

R J. Mullen
E M. Eicher
R L. Sidman

Document Type

Article

Publication Date

1976

Keywords

Ataxia: et, Body-Weight, Cerebellum: pa, Fertility, Genes-Recessive, Male, Mice, Mutation, Nerve-Degeneration, Olfactory-Bulb: pa, Purkinje-Cells: pa, Retina: pa, Spermatozoa: pa, SUPPORT-U-S-GOVT-P-H-S

First Page

208

Last Page

212

JAX Source

Proc-Natl-Acad-Sci-USA. 1976 Jan; 73(1):208-12.

Abstract

A new autosomal recessive mouse mutation, Purkinje cell degeneration (pcd), is described. Mutants exhibit a moderate ataxia beginning at 3 to 4 weeks of age. The ataxia results from postnatal degeneration of virtually all cerebellar Purkinje cells beginning around 15 to 18 days of age and progressing rapidly over the next 2 weeks. In addition to the cerebellar disease there is slow progressive degeneration in the retina (photoreceptor cells) and olfactory bulb. Also, adult males have abnormal sperm.

Recommended Citation

Mullen RJ, Eicher EM, Sidman RL. Purkinje cell degeneration, a new neurological mutation in the mouse. Proc-Natl-Acad-Sci-USA. 1976 Jan; 73(1):208-12.