Faculty Research 1970 - 1979

Title

Purkinje cell degeneration, a new neurological mutation in the mouse.

Document Type

Article

Publication Date

1976

Keywords

Ataxia: et, Body-Weight, Cerebellum: pa, Fertility, Genes-Recessive, Male, Mice, Mutation, Nerve-Degeneration, Olfactory-Bulb: pa, Purkinje-Cells: pa, Retina: pa, Spermatozoa: pa, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Proc-Natl-Acad-Sci-USA. 1976 Jan; 73(1):208-12.

Abstract

A new autosomal recessive mouse mutation, Purkinje cell degeneration (pcd), is described. Mutants exhibit a moderate ataxia beginning at 3 to 4 weeks of age. The ataxia results from postnatal degeneration of virtually all cerebellar Purkinje cells beginning around 15 to 18 days of age and progressing rapidly over the next 2 weeks. In addition to the cerebellar disease there is slow progressive degeneration in the retina (photoreceptor cells) and olfactory bulb. Also, adult males have abnormal sperm.

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