Faculty Research 1970 - 1979

Title

Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines.

Document Type

Article

Publication Date

1977

Keywords

Cell-Line, Chromosome-Mapping, Crossing-Over-(Genetics), Genes, Genotype, Glucosephosphate-Dehydrogenase: bi, Isoenzymes: bi, Linkage-(Genetics), Mice, Mice-Inbred-Strains, Mouse-Leukemia-Viruses: gd, Phosphogluconate-Dehydrogenase: bi, Polymorphism-(Genetics), Recombination-Genetic, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J-Virol. 1977 Jul; 23(1):106-9.

Abstract

Multiple recombinant inbred lines, derived from crosses between strains permissive to N-tropic murine leukemia viruses (Fv-1n) and strains permissive to B-tropic murine leukemia viruses (Fv-1b), have been characterized as to Fv-1 genotype and other chromosome 4 markers, including the closely linked hexose-6-phosphate dehydrogenase isozyme locus (Gpd-1). Only one recombinant between Fv-1 and Gpd-1 was found among 45 lines tested. On this basis, the distance between Fv-1 and Gpd-1 is estimated to be 0.6 centimorgans. None of the lines was either resistant or susceptible to both N- and B-tropic viruses. Nineteen other inbred strains, previously untested, were characterized as either Fv-1n or Fv-1b.

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