Faculty Research 1970 - 1979

Title

[Study of H-2 mutations in mice. VII. The defectiveness of the H-2ba mutant in the hemagglutination and graft vs host reactions]

Document Type

Article

Publication Date

1977

Keywords

Animal, English-Abstract, Erythrocytes: im, Graft-vs-Host-Reaction, H-2-Antigens: an, Haploidy, Hemagglutination-Tests, Isoantigens: an, Mice, Mice-Inbred-Strains: ge, im, Mutation, Spleen: im

JAX Source

Genetika. 1977; 13(1):64-9.

Abstract

Three mutants of the H-2K gene within the mouse major histocompatibility complex were studied. Antisera anti-H-2.5 + 39 were unable to agglutinate H-2ba and H-2bf mutant red blood cells. The same sera moderately agglutinated H-2b red blood cells. The H-2ba red blood cells did not absorb in vitro the activity from an anti-H-2.5 serum, while the H-2b cells did. Thus, these results indicate the existence of qualitative SD antigenic differences among H-2Kb derived mutants. In the proliferative graft versus host test the H-2ba spleen cells did not induce spleen enlargement in the H-2bd recipients, while pronounced reaction was recovered in bd-ba combination. The (baXb) F1 hybrid cells were as efficient as b/b homozygous cells. The data suggest that the H-2K gene product may be involved in the antigen recognition process by T cells.

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