Faculty Research 1970 - 1979

Title

Chromosomal location of soluble glutamic-pyruvic transaminase-1 (Gpt-1) in the mouse.

Document Type

Article

Publication Date

1977

Keywords

Alleles, Animal, Chromosome-Mapping, Crosses-Genetic, Female, Formazans, Genes, Linkage-(Genetics), Liver: en, Male, Mice, Mice-Inbred-Strains, Polymorphism-(Genetics), SUPPORT-U-S-GOVT-P-H-S

JAX Location

42,056

JAX Source

Biochem-Genet. 1977 Feb; 15(1-2):1-8.

Abstract

Three alleles at the Gpt-1 (glutamic-pyruvic transaminase-1) locus in the mouse, as identified by electrophoresis on cellulose acetate, and their distribution among inbred mouse strains and wild stocks are described. The Gpt-1 locus was shown to control the soluble form of the enzyme. Three-point linkage analysis established th location of Gpt-1 on chromosome 15 between uw and bt. In addition, a new staining procedure is described that allows the visualization of GPT activity on gels by the deposition of formazan. This is an improvement over previous methods that produced bands of nonfluorescence against a fluorescent background.

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