Faculty Research 1970 - 1979

Title

Reactivity to SV40 T antigen in athymic (nude), anti-thymocyte serum-treated, and normal mice.

Document Type

Article

Publication Date

1977

Keywords

Antigens-Neoplasm, Antilymphocyte-Serum, Mice, Mice-Inbred-BALB-C, Mice-Inbred-CBA, Mice-Nude, SUPPORT-U-S-GOVT-P-H-S, SV40-Virus: im, T-Lymphocytes: im

JAX Source

J Immunol 1977 Jul;119(1):79-82

Abstract

Antisera prepared in syngeneic mice by hyperimmunization with intact SV40-transformed mouse cells or with somatic cell hybrids between SV40-transformed human and normal mouse cells exhibit anti-SV40 tumor (T) antigen reactivity. Athymic mice bearing tumors formed by SV40-transformed mouse, human or mouse-human hybrids were not reactive with SV40 T antigen. Anti-thymocyte serum (ATS)-treated mice also lacked T antigen reactivity during suppressive treatment but developed antibody to T antigen after discontinuing ATS treatment and tumor regression. We conclude that that presence of growing tumors in the mouse is not necessary for the production of anti-SV40 T antigen antibodies but that helper thymus-derived cells are essential for the humoral response.

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