Faculty Research 1970 - 1979

Title

Assignment of genes to regions of mouse chromosomes.

Document Type

Article

Publication Date

1978

Keywords

Azure-Stains, Chromosome-Mapping: mt, Linkage-(Genetics), Mice, SUPPORT-U-S-GOVT-P-H-S, Translocation-(Genetics)

JAX Location

42,515

JAX Source

Proc-Natl-Acad-Sci-USA. 1978 Feb; 75(2):946-50.

Abstract

A genetic mapping procedure, called the duplication-deficiency method, is described. This method permits the genetic location of a translocation to be determined within a linkage group without the use of recombination. By utilizing the duplication-deficiency method to define the genetic breakpoints for a series of translocations involving a given chromosome and integrating this information with their cytological breakpoints, obtained by Giemsa banding, a genetic map of the chromosomes is constructed whereby groups of loci are assigned to banded regions. Duplication-deficiency mapping and Giemsa banding analysis of the T(X;7)1Ct and T(7;19)145H translocations together with information from the c25H deletion have permitted mouse chromosome 7 to be divided into six and chromosome 19 into two definable genetic regions.

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