Alteration of islet cell populations in spontaneously diabetic mice.

Authors

D Baetens
Y Stefan
M Ravazzola
Lagae F. Malaisse
D L. Coleman
L Orci

Document Type

Article

Publication Date

1978

Keywords

Diabetes-Mellitus: me, pa, ve, Disease-Models-Animal, Fluorescent-Antibody-Technic, Glucagon: me, Insulin: me, Islands-of-Langerhans: me, pa, Mice, Mice-Inbred-C57BL, Mice-Obese, Obesity-in-Diabetes: me, pa, Peptides: me, Somatostatin: me, SUPPORT-U-S-GOVT-P-H-S

First Page

1

Last Page

7

JAX Location

42,446

JAX Source

Diabetes. 1978 Jan; 27(1):1-7.

Abstract

Endocrine-cell populations in the islets of Langerhans of mutant mice with a severe hypoinsulinemic diabetes (ob/ob or db/db on the C57BL/KsJ background) or with a mild hyperinsulinemic diabetes (ob/ob or db/db on the C57BL/6J background) were studied quantitatively by immunofluorescence and morphometry. In severely diabetic mice, islets presented a reduced proportion of insulin containing cells but increased glucagon-, somatostatin-, and pancreatic polypeptide (PP)-containing cells, as compared with islets of control (+/+) mice. An inverse change was observed in islets of mildly diabetic mice: islets were hypertrophic and composed mostly of insulin-containing cells, with decreased proportions of glucagon-, somatostatin-, and PP-containing cells. In both types of diabetic syndromes, the changes in cell populations induced a qualitative alteration of cellular interrelationships in the affected islets.

Recommended Citation

Baetens D, Stefan Y, Ravazzola M, Malaisse LF, Coleman DL, Orci L. Alteration of islet cell populations in spontaneously diabetic mice. Diabetes. 1978 Jan; 27(1):1-7.