Faculty Research 1970 - 1979

Title

Alteration of islet cell populations in spontaneously diabetic mice.

Document Type

Article

Publication Date

1978

Keywords

Diabetes-Mellitus: me, pa, ve, Disease-Models-Animal, Fluorescent-Antibody-Technic, Glucagon: me, Insulin: me, Islands-of-Langerhans: me, pa, Mice, Mice-Inbred-C57BL, Mice-Obese, Obesity-in-Diabetes: me, pa, Peptides: me, Somatostatin: me, SUPPORT-U-S-GOVT-P-H-S

JAX Location

42,446

JAX Source

Diabetes. 1978 Jan; 27(1):1-7.

Abstract

Endocrine-cell populations in the islets of Langerhans of mutant mice with a severe hypoinsulinemic diabetes (ob/ob or db/db on the C57BL/KsJ background) or with a mild hyperinsulinemic diabetes (ob/ob or db/db on the C57BL/6J background) were studied quantitatively by immunofluorescence and morphometry. In severely diabetic mice, islets presented a reduced proportion of insulin containing cells but increased glucagon-, somatostatin-, and pancreatic polypeptide (PP)-containing cells, as compared with islets of control (+/+) mice. An inverse change was observed in islets of mildly diabetic mice: islets were hypertrophic and composed mostly of insulin-containing cells, with decreased proportions of glucagon-, somatostatin-, and PP-containing cells. In both types of diabetic syndromes, the changes in cell populations induced a qualitative alteration of cellular interrelationships in the affected islets.

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