Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.

Authors

C M. Wilson
E G. Erd:os
J D. Wilson
B A. Taylor

Document Type

Article

Publication Date

1978

Keywords

Chromosomes: me, Crosses-Genetic, Genes-Regulator, Mice, Mice-Inbred-Strains, Recombination-Genetic, Renin: ge, me, Submandibular-Gland: en, SUPPORT-U-S-GOVT-P-H-S

First Page

5623

Last Page

5626

JAX Source

Proc-Natl-Acad-Sci-USA. 1978 Nov; 75(11):5623-6.

Abstract

Renin activity (EC 3.4.99.19) was measured in submaxillary gland extracts from four sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity in androgen-treated female mice of all recombinant inbred strains resembled that of one or the other progenitor strains, as expected if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.

Recommended Citation

Wilson CM, Erd:os EG, Wilson JD, Taylor BA. Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse. Proc-Natl-Acad-Sci-USA. 1978 Nov; 75(11):5623-6.