Faculty Research 1970 - 1979

Title

Epidermis is the site of action of tabby (Ta) in the mouse.

Document Type

Article

Publication Date

1978

Keywords

Epidermis: ph, Female, Genes-Dominant, Hair: ab, Male, Mice, Mice-Inbred-C57BL, Mice-Mutant-Strains: ge, Phenotype, Skin: tr, SUPPORT-U-S-GOVT-P-H-S, Translation-Genetic, Transplantation: mt

JAX Source

Genetics. 1978 Sep; 90(1):125-31.

Abstract

The site of action of the sex-linked tabby (Ta) locus was analyzed by the technique of dermal-epidermal recombination grafting. Skin components from normal and tabby 14-day embryos were separated, recombined and grown 21 days in testes of histocompatible mice. Grafts of the combinations normal epidermis-normal dermis and normal epidermis-tabby dermis produced predominantly zig-zag hairs. Grafts of the combination tabby epidermis-normal dermis and tabby epidermis-tabby dermis produced hairs with a morphology similar to hairs found in tabby mice. We conclude from these results that the tabby locus acts within the epidermis, and has no effect on the dermis.

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