Faculty Research 1970 - 1979

Title

Transmissible murine colonic hyperplasia.

Document Type

Article

Publication Date

1978

Keywords

Citrobacter, Colitis: pa, ve, Colon: pa, Colonic-Diseases: pa, ve, Comparative-Study, Enterobacteriaceae-Infections: pa, ve, Female, Hyperplasia, Intestinal-Mucosa: pa, Male, Mice, Rodent-Diseases: pa, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Vet-Pathol. 1978 Mar; 15(2):223-36.

Abstract

After exposure to a variant of Citrobacter freundii, suckling and adult mice developed transmissible murine colonic hyperplasia of the same degree of severity. Mucosal hyperplasia was most severe 2 to 3 weeks after inoculation and then regressed. Suckling mice had a high mortality because of secondary inflammatory and erosive changes. Severe hyperplasia was characterized by mitotic activity along the entire crypt column and surface mucosa.

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