Faculty Research 1970 - 1979

Title

T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.

Document Type

Article

Publication Date

1978

Keywords

Antigens, Cytotoxicity-Tests-Immunologic, H-2-Antigens, Immune-Sera, Leukocyte-Culture-Test-Mixed, Mice, Mutation, Phenotype, T-Lymphocytes: im

JAX Source

J-Exp-Med. 1978 May 1; 147(5):1395-1404.

Abstract

We have determined the Ly phenotype of the T lymphocytes which proliferate in response to mutant H-2K and H-2D alloantigens in primary mixed lymphocyte culture. Responder T cells proliferating in reciprocal cultures of H-2d(KdDd) and H-2da(KdDda) lymphocytes were typed Ly 2+ through selective depletion with specific alloantiserum plus complement. Further, B6-Ly 1a lymphocytes proliferating in response to B6-H-2ba and B6-H-2bf stimulators were typed as Ly 1+2+ through similar analysis. These results are discussed with regard to their impact on views of lymphocyte differentiation and factors determining the identity of alloreactive lymphocytes.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS