Faculty Research 1970 - 1979

Title

Regulation of the rate of beta-galactosidase synthese by the Bgs and Bgt loci in the mouse.

Document Type

Article

Publication Date

1978

Keywords

Animal, Beta-Galactosidases: bi, ge, Comparative-Study, Galactosidases: ge, Kidney: en, Kinetics, Liver: en, Mice, Organ-Specificity, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J Biol Chem 1978 Aug 10; 253(15):5280-2.

Abstract

We have developed an assay for the in vivo rate of beta-galactosidase synthesis in mouse tissues to assess the mechanism by which the Bgs and Bgt loci regulate activity levels of this enzyme. Genetically determined differences in liver and kidney beta-galactosidase content reflect equivalent differences in specific rates of enzyme synthesis. We conclude that Bgs and Bgt regulate beta-galactosidase activity by controlling the rate of synthesis of the beta-galactosidase molecule.

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