Faculty Research 1970 - 1979

Title

Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).

Document Type

Article

Publication Date

1978

Keywords

Antibodies-Neoplasm, Antigen-Antibody-Reactions, Antigens-Neoplasm, Cell-Line, Complement, Embryo, Female, Mice, Ovum-Implantation, Pregnancy, SUPPORT-U-S-GOVT-P-H-S, Teratoma

JAX Source

Proc Natl Acad Sci U S A 1978 Nov;75(11):5565-9

Abstract

A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described. This antibody, which reacts with embryonal carcinoma cells of mouse and human origin and with some preimplantation stage mouse embryos, defines an embryonic stage-specific antigen. This stage-specific antigen (SSEA-1) is first detected on blastomeres of 8-cell stage embryos. Trophectodermal cells are transitorily positive; however, each cell in the inner cell mass eventually expresses this antigen.

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