Faculty Research 1970 - 1979
Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Document Type
Article
Publication Date
1978
Keywords
Antibodies-Neoplasm, Antigen-Antibody-Reactions, Antigens-Neoplasm, Cell-Line, Complement, Embryo, Female, Mice, Ovum-Implantation, Pregnancy, SUPPORT-U-S-GOVT-P-H-S, Teratoma
First Page
5565
Last Page
5569
JAX Source
Proc Natl Acad Sci U S A 1978 Nov;75(11):5565-9
Abstract
A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described. This antibody, which reacts with embryonal carcinoma cells of mouse and human origin and with some preimplantation stage mouse embryos, defines an embryonic stage-specific antigen. This stage-specific antigen (SSEA-1) is first detected on blastomeres of 8-cell stage embryos. Trophectodermal cells are transitorily positive; however, each cell in the inner cell mass eventually expresses this antigen.
Recommended Citation
Solter D,
Knowles BB.
Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1). Proc Natl Acad Sci U S A 1978 Nov;75(11):5565-9