Faculty Research 1970 - 1979

Title

Development of velvet coat (Ve/Ve), another early lethal mutation in the house mouse.

Document Type

Article

Publication Date

1979

Keywords

Blastocyst, Embryo-Resorption, Female, Genes-Lethal, Homozygote, Mesoderm, Mice: ge, Pregnancy, SUPPORT-U-S-GOVT-P-H-S, Time-Factors

JAX Source

Anat-Embryol-(Berl). 1979 Oct; 157(2):237-42.

Abstract

A new semidominant mutation in the house mouse, velvet coat (Ve), is described. Ve homozygotes, recognizable on day 5 of gestation by their deficiency of ectodermal cells, never produce mesoderm and are resorbed by days 9-10. Primary Ve action may occur during the formation of the blastocyst or during determination and differentiation of the inner cell mass, or both. Accordingly, Ve/Ve embryos may provide a useful model for investigating primary gene action during blastocyst formation and subsequent differentiation.

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