Independence of uniphasic and biphasic audiogenic seizure progressions in mice.

Authors

H M. Reid
R L. Collins

Document Type

Article

Publication Date

1989

Keywords

Animal, Arousal, Auditory-Perception, Dominance-Cerebral, Mice, Mice-Inbred-DBA, Motor-Activity, Reaction-Time, Seizures: px, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

First Page

417

Last Page

421

Grant

GM23618

Abstract

DBA/2J mice were monaurally or binaurally tested for susceptibility to sound-induced seizure. Two seconds following the beginning of running, one group of binaurally tested mice had acoustic stimulation interrupted for 15 s. These mice later seized when the stimulation was readministered. Their seizure progression closely resembled the behavior exhibited by noninterrupted binaurally stimulated mice and did not shift to the biphasic motor pattern of monaurally stimulated subjects. We conclude that the single burst of running of a binaurally tested mouse is qualitatively different from either of the two bursts of running exhibited by monaurally tested mice.

Recommended Citation

Reid HM, Collins RL. Independence of uniphasic and biphasic audiogenic seizure progressions in mice. . 1989; ():417