Faculty Research 1980 - 1989
Autosomal aneuploidy in mice: generation and developmental consequences.
Document Type
Article
Publication Date
1986
Keywords
Animal, Chimera, Disease-Models-Animal, Mice, Mice-Neurologic-Mutants: ge, Phenotype, Review, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Translocation-(Genetics), Trisomy
First Page
789
Last Page
801
JAX Location
1,338.
JAX Source
Brain-Res-Bull. 1986 Jun; 16(6):789-801.
Grant
HD16303, HD17784
Abstract
Spontaneous aneuploidy in the mouse is uncommon, but specific mating schemes have been developed that produce aneuploid conceptuses at high frequencies. The most commonly reported aneuploid condition in the mouse is autosomal trisomy, in which there is an extra copy (in whole or in part) of a chromosome. In this review, we present several of the schemes used in producing trisomic, partially (tertiary) trisomic, and monosomic conceptuses and summarize the developmental consequences that are associated with each of the autosomal trisomies of the mouse.
Recommended Citation
Gearhart JD,
Davisson MT,
Oster GM.
Autosomal aneuploidy in mice: generation and developmental consequences. Brain-Res-Bull. 1986 Jun; 16(6):789-801.