Faculty Research 1990 - 1999

Title

Recombination in the mammalian germ line.

Document Type

Article

Publication Date

1998

JAX Source

Curr Top Dev Biol 1998;37:1-35

Abstract

Elucidation of meiotic recombination mechanisms in mammals faces many obstacles. Much of our understanding has been built upon studies in the fungi, which have served to guide experimental design in mammalian cells and mice. A clearer picture is now emerging which reveals that many of the general principles of recombination are conserved across this evolutionary divide. A number of genes critical to meiotic recombination in yeast also exist in mammals. Transgenic technologies, in addition to advances in molecular biology, now provide several strategies to investigate the properties and regulation of mammalian recombination. This chapter reviews the current state of knowledge regarding recombination in the mammalian germ line, covering topics such as gene conversion, recombination mechanics, recombination-based genetic mutation, crossing over, and genes involved in meiotic recombination.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS