Faculty Research 1990 - 1999
Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice.
Document Type
Article
Publication Date
1998
First Page
25
Last Page
35
JAX Source
Cell Transplant 1998 Jan-Feb;7(1):25-35
Abstract
Antibodies to the ligand for CD40 (CD154) have been shown to exert profound effects on the development of cell-mediated immune responses in mice. The present study shows that an antibody to human CD154 (hCD40L) inhibits in vivo Tetanus toxoid (TT) specific secondary antibody responses in hu-PBL-scid mice, as well as the expansion of xenoreactive human T cells in the scid mice. A possible cause for the reduced expansion of xenoreactive, human T cells, was the decreased expression of murine B7.1 and B7.2 caused by the administration of anti-hCD40L. Therefore, it may be that defective maturation of murine antigen-presenting cells impeded the priming and expansion of human xenoreactive T cells.
Recommended Citation
Foy TM,
McIlraith M,
Masters SR,
Dunn JJ,
Rossini AA,
Shultz LD,
Hesselton RA,
Wagar EJ,
Lipsky PE,
Noelle RJ,
Greiner DL.
Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice. Cell Transplant 1998 Jan-Feb;7(1):25-35