Faculty Research 1990 - 1999

Title

Cryopreservation and orthotopic transplantation of mouse ovaries: new approach in gamete banking.

Document Type

Article

Publication Date

1998

Keywords

Animal, Cryopreservation, Female, Mice, Mice-Inbred-C57BL, Ovarian-Follicle, Ovariectomy, Ovary, Pregnancy

JAX Source

Biol Reprod 1998 Apr;58(4):1071-4

Grant

RR01181/RR/NCRR, RR09781/RR/NCRR, RR01262/RR/NCRR

Abstract

Mouse half ovaries were cryopreserved and orthotopically transplanted into ovariectomized recipients genetically identical to ovary donors except for the coat color gene. Fertility was reestablished in 57% of the female recipients, which became pregnant in an average of 40 days after transplantation of frozen-thawed half ovaries. These experiments demonstrate that ovary cryopreservation can be a very useful option for banking mouse germplasm, or managing subfertile animal colonies, when embryo or sperm freezing cannot be used or is not cost effective.

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