Faculty Research 1990 - 1999

Title

Osteosarcomas in transgenic mice expressing an alpha-amylase-SV40 T-antigen hybrid gene.

Document Type

Article

Publication Date

1990

Keywords

Animal, Antigens-Polyomavirus-Transforming: ge, me, Bone-Neoplasms: ge, me, pa, Cell-Line, Cloning-Molecular, Mice, Mice-Transgenic: ge, Osteosarcoma: ge, me, pa, Promoter-Regions-(Genetics), SUPPORT-U-S-GOVT-P-H-S, Tumor-Cells-Cultured: me, pa

JAX Source

Am J Pathol 1990 Aug;137(2):259-62

Grant

CA10815/CA/NCI, CA18470/CA/NCI, CA21124/CA/NCI

Abstract

Mice of a transgenic mouse lineage 501, produced by zygotic injection of the parotid alpha-amylase promoter-SV40 T-antigen hybrid gene, developed osteosarcomas at about 15 months of age. The tumors predominantly involved the axial skeleton, were sometimes multiple, and metastasized to the liver. A cell line derived from a primary tumor produced osteosarcomas on transfer to nude mice. The 501 transgenic lineage thus provides a valuable new model for studying the histogenesis of osteosarcomas.

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