Faculty Research 1990 - 1999

Title

Remodeling of the HDL in NIDDM: a fundamental role for cholesteryl ester transfer protein.

Document Type

Article

Publication Date

1998

Keywords

Animal, Apolipoprotein A-I/metabolism, Blood Glucose/metabolism, Carrier Proteins/genetics/*physiology, Chemistry, Physical, Diabetes Mellitus, Non-Insulin-Dependent/*blood, Female, Gene Expression, Insulin, Lipase, Lipoproteins, HDL, Male, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Mice, Transgenic, Phospholipids Triglycerides

JAX Source

Am J Physiol 1998 Jun;274(6 Pt 1):E1091-8

Abstract

When the Ay gene is expressed in KK mice, the yellow offspring (KKAy mice) become obese, insulin resistant, hyperglycemic, and severely hypertriglyceridemic, yet they maintain extraordinarily high plasma high-density lipoprotein (HDL) levels. Mice lack the ability to redistribute neutral lipids among circulating lipoproteins, a process catalyzed in humans by cholesteryl ester transfer protein (CETP). To test the hypothesis that it is the absence of CETP that allows these hypertriglyceridemic mice to maintain high plasma HDL levels, simian CETP was expressed in the KKAy mouse. The KKAy-CETP mice retained the principal characteristics of KKAy mice except that their plasma HDL levels were reduced (from 159 +/- 25 to 25 +/- 6 mg/dl) and their free apolipoprotein A-I concentrations increased (from 7 +/- 3 to 22 +/- 6 mg/dl). These changes appeared to result from a CETP-induced enrichment of the HDL with triglyceride (from 6 +/- 2 to 60 +/- 18 mol of triglyceride/mol of HDL), an alteration that renders HDL susceptible to destruction by lipases. These data support the premise that CETP-mediated remodeling of the HDL is responsible for the low levels of that lipoprotein that accompany hypertriglyceridemic non-insulin-dependent diabetes mellitus.

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