Faculty Research 1990 - 1999

Title

Juvenile bare: a new hair loss mutation on chromosome 7 of the mouse.

Document Type

Article

Publication Date

1998

Keywords

Alopecia/*genetics/pathology, Chromosome Mapping, Genes, Recessive, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Mutant Strains, Mutation

JAX Source

J Hered 1998 May-Jun;89(3):254-7

Grant

CA34196/CA/NCI

Abstract

We describe a new juvenile hair loss mutant in the mouse in which the hair follicle follows irregular pathways to the surface and generally becomes dystrophic when the mouse is about 23 days of age. Skin from mutant mice older than 1 month of age is histologically normal, although adult mutant mice show a slightly more sparse coat than normal. Grafts of mutant littermates skin to SCID hosts indicate that the condition is probably a systemic response rather than one of the follicle per se. The hair loss is caused by a recessive mutation, which we have named juvenile bare (jb), located on proximal chromosome 7.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS