Faculty Research 1990 - 1999
Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.
Document Type
Article
Publication Date
1998
First Page
205
Last Page
208
JAX Source
Genomics 1998 Sep 1;52(2):205-8
Grant
NS35900/NS/NINDS, P30CA34196/CA/NCI
Abstract
The vertebrate Unc5 genes, like their Caenorhabditis elegans counterpart, define a family of putative netrin receptors. One member of this family, Unc5h3, has been shown to have an important role during cell migration in the developing murine cerebellum. Mice homozygous for mutations in Unc5h3 are ataxic and have cerebellar hypoplasia and laminar structure defects. In addition, these mice have ectopic granule and Purkinje cells in the midbrain and brainstem. We have identified the human homologue of this gene, UNC5C, and shown it to have a restricted expression pattern in adult human tissues. By radiation hybrid analysis, we have determined that UNC5C localizes to chromosome 4q21-q23 between markers D4S1557 and D4S836 and is closely linked to the Parkinson disease gene. Copyright 1998 Academic Press.
Recommended Citation
Ackerman SL,
Knowles BB.
Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. Genomics 1998 Sep 1;52(2):205-8