Faculty Research 1990 - 1999
Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3 and PC12 cells.
Document Type
Article
Publication Date
1990
Keywords
Amino-Acid-Sequence, Animal, Base-Sequence, Cell-Line, DNA: ge, Fibroblast-Growth-Factor, Gene-Library, Growth-Substances, Half-Life, Mice, Molecular-Sequence-Data, Peptides: bi, ge, me, Pheochromocytoma, Platelet-Derived-Growth-Factor, Proteins: bi, ge, me, Rats, RNA-Messenger: ge, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Tetradecanoylphorbol-Acetate
First Page
6769
Last Page
6774
JAX Source
Mol Cell Biol 1990 Dec;10(12):6769-74
Grant
RO1CA46565/CA/NCI, RO1CA52220/CA/NCI
Abstract
pip92 is a cellular immediate-early gene inducible by serum growth factors in fibroblasts. It is also induced in the rat pheochromocytoma cell line PC12 by agents that cause proliferation, neuronal differentiation, and membrane depolarization. We show that the pip92-encoded polypeptide is a proline-rich protein of 221 amino acids, has an extremely short half-life, and is localized in the cytoplasm. We hypothesize that Pip92 plays a role in mediating the cellular responses to a variety of extracellular signals.
Recommended Citation
Charles CH,
Simske JS,
O'Brien TP,
Lau LF.
Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3 and PC12 cells. Mol Cell Biol 1990 Dec;10(12):6769-74