Faculty Research 1990 - 1999
Rate of accumulation of Luxol Fast Blue staining material and mitochondrial ATP synthase subunit 9 in motor neuron degeneration mice.
Document Type
Article
Publication Date
1998
Keywords
Disease-Models-Animal, Dyes: me, H(+)-Transporting-ATP-Synthase: me, Hippocampus: en, me, Indoles: me, Mice, Mice-Inbred-C57BL, Mice-Mutant-Strains, Mitochondria: en, Motor-Neurons: pa, Neuronal-Ceroid-Lipofuscinosis: en, me, SUPPORT-U-S-GOVT-P-H-S
First Page
1291
Last Page
1296
JAX Source
Neurochem Res 1998 Oct;23(10):1291-6
Grant
NS30153/NS/NINDS, NS30148/NS/NINDS
Abstract
The rate of accumulation of Luxol Fast Blue staining material in the hippocampus of motor neuron degeneration (mnd/mnd) mice, a model of Batten Disease, was quantitated. Stained material increased linearly up to 8 months of age. A quantitative immunoassay was used to measure levels of mitochondrial ATP synthase subunit 9 in brain and liver of mnd/mnd mice. Levels of subunit 9 increased progressively throughout the lifespan of mnd/mnd mice reaching levels approximately 5-fold higher than in control animals. The rate of accumulation of subunit 9 is not consistent with any simple complete or partial degradation defect that is constant throughout the animal's life. Two more complicated models are discussed which are consistent with the observed accumulation rate of subunit 9.
Recommended Citation
Rodman JS,
Lipman R,
Brown A,
Bronson RT,
Dice JF.
Rate of accumulation of Luxol Fast Blue staining material and mitochondrial ATP synthase subunit 9 in motor neuron degeneration mice. Neurochem Res 1998 Oct;23(10):1291-6