Faculty Research 1990 - 1999

Title

A new allelic series for the underwhite gene on mouse chromosome 15.

Document Type

Article

Publication Date

1998

Keywords

Animal, Base-Sequence, Chromosome-Mapping, DNA, Eye-Color: ge, Female, Hair-Color: ge, Linkage-(Genetics), Male, Mice, Mice-Inbred-C57BL, Microscopy-Electron, Pigment-Epithelium-of-Eye: cy, ul, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J Hered 1998 Nov-Dec;89(6):546-51

Grant

GM22167/GM/NIGMS, CA06927/CA/NCI, GM46697/GM/NIGMS

Abstract

A new allelic series at the underwhite gene is described. Three of the alleles in the series--uw, uwd, and Uwdbr--arose as spontaneous mutations on different genetic backgrounds at The Jackson Laboratory. We report here the visible phenotypes and dominance hierarchy of these alleles, all of which are defined by a reduction of pigmentation in both eye and coat color. Electron microscopic analysis of retinal epithelium suggests that the primary defect is in the melanosome. The degree of severity of melanosome anomalies in the retina correlates with the degree of hypopigmentation in the coat. The perturbed gene and its gene product are unknown. We show that the uw locus is genetically distinct from Myo10, a suggested candidate gene for this mutation.

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