Faculty Research 1990 - 1999

Title

Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.

Document Type

Article

Publication Date

1998

JAX Source

Genomics 1998 Dec 15;54(3):556-9

Grant

P40RR01183/RR/NCRR, 37GM36745/GM/NIGMS

Abstract

Patchy fur is a semidominant X-linked mutation in the mouse, resulting in a sparse coat. The Paf mutation also alters the normal segregation of the X and the Y chromosomes during male meiosis by causing nondisjunction at anaphase I. Analysis of 1139 female meioses from an intersubspecific backcross using 15 PCR-based markers localizes Paf to an approximately 0.2-cM interval that includes the pseudoautosomal boundary. The meiotic nondisjunction phenotype may result from a chromosomal rearrangement that includes pseudoautosomal sequences and affects XY pairing. Copyright 1998 Academic Press.

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