Faculty Research 1990 - 1999

Title

The molecular biology of polycystic kidney disease.

Document Type

Article

Publication Date

1998

Keywords

Mice, Polycystic-Kidney-Diseases, Polycystic-Kidney-Autosomal-Dominant, Polycystic-Kidney-Autosomal-Recessive, Proteins, Receptor-Epidermal-Growth-Factor, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Pediatr-Nephrol 1998 Nov; 12(9):721-6.

Grant

DK51068/DK/NIDDK

Abstract

In recent years there have been a number of developments in polycystic kidney disease (PKD) research. The genes associated with the predominant forms of autosomal dominant PKD have been cloned, and the gene associated with a mouse model for autosomal recessive PKD has been identified and characterized. Other studies have yielded new information regarding the role of the epidermal growth factor receptor gene in promoting renal cyst formation. In this review article we summarize recent published data on the molecular genetics of autosomal dominant and autosomal recessive PKD and provide a working model of how multiple genes participate in the PKD disease pathway.