Faculty Research 1990 - 1999
Lens epithelial proliferation cataract in segmental trisomy involving mouse Chromosomes 4 and 17.
Document Type
Article
Publication Date
1999
Keywords
Animals-Newborn, Blotting-Northern, Blotting-Southern, Cataract: ge, Cell-Division, Chromosome-Abnormalities, Chromosomes: ge, DNA: an, ge, Epithelial-Cells: cy, Female, Lens-Crystalline: me, pa, Male, Mice, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Inbred-DBA, SUPPORT-U-S-GOVT-P-H-S, Trisomy
First Page
102
Last Page
106
JAX Source
Mamm Genome 1999 Feb;10(2):102-6
Grant
CA34196/CA/NCI, RO1EY07758/EY/NEI, RRO1183
Abstract
A dominant induced mutation in the mouse, tightly associated with a reciprocal chromosomal translocation between Chrs 4 and 17, causes abnormal head tossing and circling behavior (the translocation induced circling mutation, Tim). Affected mice develop an unusual anterior subcapsular cataract that appears after birth and is progressive. The most likely explanation for the phenotypic observations is that the translocation breakpoint disrupted a gene or its regulation. Although the Mos protooncogene is located close to the translocation breakpoint and transgenic mice that overexpress Mos demonstrate cataracts and circling behavior, there were no gross changes in the Mos gene or in its level of expression. The morphological changes observed in the lens resemble those seen in some human congenital cataract syndromes.
Recommended Citation
Smith RS,
Johnson KR,
Hawes NL,
Harris BS,
Sundberg JP,
Davisson MT.
Lens epithelial proliferation cataract in segmental trisomy involving mouse Chromosomes 4 and 17. Mamm Genome 1999 Feb;10(2):102-6