Faculty Research 1990 - 1999

Title

Lens epithelial proliferation cataract in segmental trisomy involving mouse Chromosomes 4 and 17.

Document Type

Article

Publication Date

1999

Keywords

Animals-Newborn, Blotting-Northern, Blotting-Southern, Cataract: ge, Cell-Division, Chromosome-Abnormalities, Chromosomes: ge, DNA: an, ge, Epithelial-Cells: cy, Female, Lens-Crystalline: me, pa, Male, Mice, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Inbred-DBA, SUPPORT-U-S-GOVT-P-H-S, Trisomy

JAX Source

Mamm Genome 1999 Feb;10(2):102-6

Grant

CA34196/CA/NCI, RO1EY07758/EY/NEI, RRO1183

Abstract

A dominant induced mutation in the mouse, tightly associated with a reciprocal chromosomal translocation between Chrs 4 and 17, causes abnormal head tossing and circling behavior (the translocation induced circling mutation, Tim). Affected mice develop an unusual anterior subcapsular cataract that appears after birth and is progressive. The most likely explanation for the phenotypic observations is that the translocation breakpoint disrupted a gene or its regulation. Although the Mos protooncogene is located close to the translocation breakpoint and transgenic mice that overexpress Mos demonstrate cataracts and circling behavior, there were no gross changes in the Mos gene or in its level of expression. The morphological changes observed in the lens resemble those seen in some human congenital cataract syndromes.

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