Faculty Research 1990 - 1999

Title

Radiation-resistant and radiation-sensitive forms of host resistance to polyomavirus.

Document Type

Article

Publication Date

1999

Keywords

Animal, Animals, Newborn, Female, Genetic Predisposition to Disease, Immunity, Natural, Male, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Papovaviridae Infections, Polymavirus, Tumor Virus Infections

JAX Source

J Virol 1999 Feb;73(2):1213-8

Grant

R35CA44343/CA/NCI, PO1CA50661/CA/NCI

Abstract

Newborn mice of several inbred strains develop few or no tumors following inoculation with highly tumorigenic strains of polyomavirus. Here we show that such resistant strains can be divided into two groups based on the responses of adult mice to radiation followed by virus inoculation. Most strains show a radiation-sensitive form of resistance (Rr-s) and develop tumors following radiation and virus challenge. This type of resistance has previously been recognized as immunological, based on T-cell responses against virus-encoded neoantigen(s) expressed in tumor cells. Other strains exhibit a radiation-resistant form of resistance (Rr-r) and fail to develop tumors when treated in the same manner. Three additional properties of Rr-r mice distinguish them from Rr-s mice: (i) survival of newborns following inoculation with a highly virulent and usually lethal strain of virus, (ii) resistance to virus spread in newborns inoculated with either tumorigenic or virulent virus strains, and (iii) dominant or semidominant transmission of resistance in crosses with a highly susceptible strain. The Rr-r phenotype reflects a constitutive nonimmunological type of resistance that is targeted to the virus and blocks its dissemination.

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