Faculty Research 1990 - 1999

Title

The same genetic regions encode minor histocompatibility antigens detected in the context of different MHC haplotypes.

Document Type

Article

Publication Date

1999

Keywords

Antigens-Bacterial: an, ge, im, Chromosomes: ge, Epitopes: ge, Female, Graft-Rejection: im, Haplotypes: ge, Immunization, Major-Histocompatibility-Complex: ge, Mice, Mice-Inbred-Strains, Minor-Histocompatibility-Antigens: ge, Skin-Transplantation, Spleen: im, cy, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes-Cytotoxic: im

JAX Source

Transplantation 1999 Apr 27;67(8):1178-83

Grant

R01, R01, R01CA34196/CA/NCI

Abstract

The mammalian genome encodes numerous autosomal minor histocompatibilty (H) antigens that act as a barrier to allogeneic tissue transplantation when donor and recipient are matched for the major histocompatibilty complex (MHC). However, most of our understanding of the genetic basis of such minor H antigens is limited to analysis of mouse strains of the H2b haplotype. To broaden our understanding, we investigated minor H antigens detected in the context of other MHC alleles. As measured by graft survival and precursor cytotoxic T lymphocytes from blood, our results suggest that chromosomal segments known to encode minor H antigens detected in the context of the H2b haplotype are antigenically complex in that they also frequently encode minor H antigens that can be detected in the context of at least the H2d and H2k haplotypes. Genetic models to account for this complexity are discussed.

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