Faculty Research 1990 - 1999

Title

Rescue of cyclin D1 deficiency by knockin cyclin E.

Document Type

Article

Publication Date

1999

Keywords

Cyclin-D1: ge, df, me, Cyclin-E: ge, me, Human, Mice, Mice-Inbred-C57BL, Phenotype, Receptors-Estrogen: me, Retina: me, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Cell 1999 Jun 11;97(6):767-77

Grant

535CA39826/CA/NCI

Abstract

D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces that normally associated with mouse cyclin D1. The replacement of cyclin D1 with cyclin E rescues all phenotypic manifestations of cyclin D1 deficiency and restores normal development in cyclin D1-dependent tissues. Thus, cyclin E can functionally replace cyclin D1. Our analyses suggest that cyclin E is the major downstream target of cyclin D1.

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